Image Each project has a bespoke designed panel, addressing specific clinical hypotheses. We work directly with research teams to establish the clinical question at hand and determine how our cutting-edge techniques can support their projects. Core themes running throughout our collaborations include: Immune infiltration Molecular subtyping of disease AI Mediated Pathology assessments We have also embarked on an integrative multi-omic approach with FACS and multiple sequencing modalities. Gastro-oesophageal cancer ICONICCollaborator: Professor Marco GerlingerProject summary: The ICONIC trial is one of the first clinical trials to administer a chemo-immunotherapy combination in a peri-operative setting in gastro-oesophageal adenocarcinomas. We are studying changes of the immunological landscape before, during and after treatment to understand the impact of the treatment on the tumour cells and their microenvironment and to define predictive tools. FLOT-ECXCollaborator: Professor David Cunningham/Dr Avani AthaudaProject summary: This tissue collection forms the paired control group to the ICONIC sample cohort. All patients were treated with standard chemotherapy regimen. We are looking into chemotherapy related changes in the tumour microenvironment and will compare the results with the findings of the ICONIC trial cohort. SOLAR Collaborator: Dr Naureen Starling/Dr Elizabeth CartwrightProject summary: The SOLAR clinical trial treats patients with advanced gastro-oesophageal cancers with a PARP inhibitor. We will study the molecular features of the tumour cells and changes in the tumour microenvironment to define predictive tools. PLATFORMCollaborator: Professor David CunninghamProject summary: This Phase III maintenance therapy trial for advanced gastro-oesophageal cancer patients comprises different treatment arm, including immunotherapy, capecitabine and trastuzumab. We are looking into morphological, molecular and immunological features of the cancers and their outcomes in different treatment arms. TransOGCollaborator: Professor David Cunningham/Dr Justin MencelProject summary: This clinical trial cohort comprises three major trials in resectable gastro-oesophageal cancers (ST03, OE02, OE05) and forms one of the biggest clinical trial tissue cohort in this cancer type. We are studying molecular and immunological features to establish better predictive tools. Other cancers RADIO/PLUMMB bladder cancerCollaborator: Dr Anna Wilkins/Professor Nick JamesProject summary: Patterns of cells/ distinct cell types in the tumour microenvironment correlate with survival outcomes in bladder cancer following radiotherapy.